2004
Yan, B.* New
combichem QC standards guards the supply of compounds and ensure HTS results,¡± Modern Drug
Discovery. Feburary issue, 2004, 30-34.
Irving M, Krueger
CA, Wade JV, Hodges JC, Leopold K, Chan C, Shaqair S, Shornikov A, Stock M, Collins N, Yan B. High-Throughput
Purification of Combinatorial Libraries II: Automated Separation of Single Diastereomers from a 1920-Member
4-Amidopyrrolidinone Library. J Combi Chem 6, 478-486, 2004.
Jiang Zhao, Lu
Zhang, Bing Yan, Strategies and Methods for Purifying Organic Compounds and Combinatorial Libraries. In Yan, B.
Editor (2004) ¡°Analytical and purification methods in combinatorial chemistry¡± by John Wiley
and Sons, New York.
The application of
single bead FTIR and color test for reaction monitoring and building block validation in combinatorial library
synthesis. Jason J. Cournoyer, Clinton A. Krueger, Janice V. Wade, Bing Yan, In Yan, B. Editor.
¡°Analytical and purification methods in combinatorial chemistry¡± by John Wiley and Sons, New
York, 2004.
Yan B, Collins N,
Wheatley J, Irving M, Leopold K, Chan C, Shornikov A, Fang L, Lee A, Stock M, Zhao J. High-Throughput Purification
of Combinatorial Libraries I: A High-Throughput Purification System Using an Accelerated Retention Window
Approach. J Combi Chem 6, 255-261, 2004.
2003
Fang L, Zhao J, Yan
B. High throughput parallel LC/UV/MS analysis of combinatorial libraries in Methods in Enzymology Volume 369,
Pages 3-21. Combinatorial Chemistry, Part B. Edited by: Guillermo A. Morales and Barry A. Bunin,
2003.
Yan B, Tang Q.
Comparison of kinetics of organic reactions carried out on resin beads of different diameters. Industrial
and Eng Chem Res 42 (24) 5964-5967, 2003.
Yan B. Editor.
Chemical Analysis ¨C A Series of Monographs on Analytical Chemistry and Its Applications Volume 163
¡°Analytical and purification methods in Combinatorial Chemistry¡± by John Wiley and Sons, Inc.
2003.Highlighted by: Journal of Natural Products, 2004, Vol. 67, No. 6, 1076.
Angew. Chem.
Int. Ed. 2004, 43, 4552 ¨C 4553.
Drug
Development And Industrial Pharmacy, 2004, Vol. 30, No. 7, p. 793.
Yan B, Fang L,
Irving M, Zhang S, Boldi AM, Woolard F, Johnson CR, Kshirsagar T, Figliozzi GM, Krueger CA, Collins N. Quality
Control in Combinatorial Chemistry: Determination of the Quantity, Purity, and Quantitative Purity of Compounds in
Combinatorial Libraries. J Combi Chem 5(5), 547-559, 2003.
Highlighted
by Faculty of 1000 Chemistry.
MODERN DRUG
DISCOVERY SEPTEMBER issue, 2003, 11.
Fang L, Demee M,
Cournoyer J, Sierra T, Young C, Yan B. Parallel high-throughput accurate mass measurement using a nine-channel
multiplexed electrospray LC/UV/TOFMS system. Rapid Commun Mass Spectr 17, 1425-1432, 2003.
Yan B. Monitoring
and Optimizing Organic Reactions Carried Out on Solid Support. Chapter in book Polymeric Materials in Organic
Synthesis and Catalysis. Buchmeiser, M. R. Ed. Wiley-VCH, 2003.
2002
Yan B, Fang L,
Irving M, Zhao J, Liu D, Figliozzi G, Woolard F, Krueger C. Analytical Methods for Optimization and Quality
Control of Combinatorial Synthesis, chapter in Methods in Molecular Biology, Volume 201: Combinatorial Library
Methods and Protocols, English, Lisa B. Ed. By Humana Press, 2002.
Fang L, Demee M,
Sierra T, Zhao J, Tokushige D, Yan B. Optimization of an Eight-Channel Multiplexed Electrospray Time-of-Flight
Mass Spectrometry (MUX-LCT) System for Combinatorial Library Analysis. Rapid Commun Mass Spectr
16, 1440-1447, 2002.
Yan B. Single bead
analysis in combinatorial chemistry. Current Opinion in Chemical Biology 6, 328-332, 2002.
Fang L, Demee M,
Sierra T, Kshirsagar T, Celebi A, Yan B. Kinetic Study of Amine Cleavage Reactions of Various Resin-Bound
Thiophenol Esters from Marshall Linker. J Combi Chem 4, 362-368, 2002.
Cournoyer JJ,
Kshirsagar T, Fantauzzi PP, Figliozzi GM, Makdessian T, Yan B. A Color Test for the Detection of Resin-Bound
Aldehyde in Solid-Phase Combinatorial Synthesis. J Combi Chem 4, 120-124, 2002.
Yan, B., Fang, L.,
Irving, M., Zhao, J., Liu, D., Figliozzi, G., Woolard, F., Krueger. C. Analytical Methods for Optimization and
Quality Control of Combinatorial Synthesis, Methods in Molecular Biology, Volume 201: 189-200, ¡°Combinatorial
Library Methods and Protocols¡±, English, Lisa B. Ed. By Humana Press, 2002.
Yan, B.*, Fang, L.
Zhao, J. Irving, M. M. ¡°Analytical Techniques Applied in the Combinatorial Synthesis of Large Drug Discovery
Libraries,¡± Analytical Sciences, 487i-490i, 2002.
2001
Irving MM,
Kshirsagar T, Figliozzi GM, Yan B. Repeated Use of Solid Supports in Combinatorial Synthesis ¨C The Case of
Marshall Resin Recycling. J Combi Chem 3, 407-409, 2001.
Fang L, Pan J, Yan
B. High-throughput determination of identity, purity and quantity of combinatorial library members using
LC/MS/UV/ELSD. Bioeng Biotech (Combi Chem) 71, 162-171, 2001.
Yan, B., Kshiragar,
T., Fang, L., Fantauzzi, P., Pan, J. Analytical Methods in Library Feasibility and Rehearsal Studies. In Yan, B.
and Czarnik, A. Editors (2001) ¡°Optimization of solid-phase combinatorial synthesis¡± by Marcel Dekker, New York.
Yan B, Czarnik A.
Editors Optimization of solid-phase combinatorial synthesis by Marcel Dekker, New York, 2001.Highlighted
by J. Am. Chem. Soc. 9 Vol. 124, No. 26, 2002 7875
Irving M, Cournoyer
J, Li R, Santos C, Yan B. Qualitative and Quantitative Analyses of Resin-Bound Organic Compounds. Combinatorial
Chemistry and High-Throughput Screening 4, 353-362, 2001.
Yan B, Yan H.
Combination of Single Bead FTIR and Chemometrics in Combinatorial Chemistry: Application of Multivariate
Calibration Method in the Monitoring of Solid Phase Organic Synthesis. J Combi Chem 3, 78-84, 2001.
2000
Yan B, Nguyen N, Liu
L, Holland G, Raju B. Kinetic Comparison of Trifluoroacetic Acid Cleavage Reactions of Resin-Bound Carbamates,
Ureas, Secondary Amides, and Sulfonamides from Benzyl-, Benzhydryl-, and Indole-Based Linkers. J Comb Chem 2(1)
66-74, 2000.
Gremlich HU, Yan B.
Editors. Biological FTIR and Raman Spectroscopy by Marcel Dekker, New York, 2000.
Highlighted
by J. Am. Chem. Soc., Vol. 123, No. 42, 2001 10427
Yan, B.* FTIR in
Combinatorial Chemistry. Chemistry (Chinese Chemical Society, Taipei) 2000, 58(1) 139-144.
Yan B. Analytical
methods for combinatorial chemistry ¨C a practical approach. In Combinatorial Chemistry ¨C A Practical Approach by
Oxford University Press, Edited by Hicham Fenniri, 2000.
Yan, B.. (2000)
Application of single bead FTIR in the optimization of solid-phase combinatorial and parallel syntheses. Pept.
New Millennium, Proc. Am. Pept. Symp., 16th 411-413.
1999
Yan B. Vibrational
spectroscopy for optimization of solid-phase organic synthesis. In Solid-Phase Organic Synthesis by John Wiley,
Edited by Kevin Burgess, 1999.
Yan B, Gremlich H-U.
The Role of FTIR Methods in the Rehearsal Phase of Combinatorial Chemistry. J Chromatography B 725, 91-102, 1999.
Marti, R. E.;
Martin, M. S; Yan, B.; Jarosinski, M. (1999) Solid-phase synthesis via 5-oxazolidinones. Ring opening reactions
with amines and reaction monitoring by single bead FT-IR microspectroscopy. Pept. Proc. Am. Pept. Symp.15th,
305-306.
Yan B, Liu L, Astor
CA, Tang Q. Determination of the Absolute Amount of Resin-Bound Hydroxyl or Carboxyl Groups for the Optimization
of Solid-Phase Combinatorial and Parallel Organic Synthesis. Anal Chem 71(20) 4564-4571, 1999.
Yan B. Analytical
methods in combinatorial chemistry by CRC Press (now Taylor & Francis), 1999.
Highlighted
by Journal of Medicinal Chemistry, 2001, Vol. 44, No. 20, 3334.
Yan B, Martin PC,
Lee J. Single Bead Fluorescence Microspectroscopy: Detection of Self-Quenching in Fluorescence-Labeled Resin
Beads. J Combin Chem 1, 78-81, 1999.
Yan B, Gremlich H-U,
Moss S, Coppola GM, Sun Q, Liu L. A comparison of various FTIR and FT raman methods: applications in the reaction
optimization stage of combinatorial chemistry. J Combi Chem 1, 46-54, 1999.
1998
Jackson JC, Vinluan
CC, Dragland CJ, Sundararajan V, Yan B, Gounarides JS, Nirmala NR, Topiol S, Ramage P, Blume JE, Aicher TD, Bell
PA, Mann WR. Heterologously expressed inner lipoyl domain of dihydrolipoyl acetyltransferase inhibits
ATP-dependent inactivation of pyruvate dehydrogenase complex: Identification of important amino acid residues.
Biochem J 334, 703-711, 1998.
Yan B. Monitoring
the progress and the yield of solid-phase organic reactions directly on resin supports. Acct Chem
Res 31, 621-630, 1998.
Yan B, Jewell Jr CF,
Myers SW. Quantitatively monitoring of solid-phase organic synthesis by combustion elemental analysis.
Tetrahedron 54, 11755-11766, 1998.
Li W, Yan B. Effects
of Polymer Supports on the Kinetics of Solid-Phase Organic Reactions: A Comparison of Polystyrene- and
TentaGel-Based Resins. J Org Chem 63, 4092-4097, 1998.
Sun Q, Yan B. Single
bead IR monitoring a novel benzimidazole synthesis. Bioorg Med Chem Lett 8, 361-364, 1998.
Yan B, Sun Q.
Crucial factors regulating site-interactions in resin supports determined by single bead IR. J Org Chem
63, 55-58, 1998.
Yan B. Properties of
solid supports and their effects on solid-phase organic synthesis. Combinatorial Chemistry and
High-Throughput Screening 1, 215-229, 1998.
1997
Shapiro M, Lin M,
Yan B. Analytical Tools for Combinatorial Chemistry in (ACS Book) Combinatorial Chemistry: A Short Course, S. H.
DeWitt and A. W. Czarnik, Editors, 1997.
Yan B, Li W. Rapid
fluorescence determination of the absolute amount of aldehyde and ketone groups on resin supports. J Org Chem 62,
9354-9357, 1997.
Li W, Yan B. A
direct comparison of the mixing efficiency in solid-phase organic synthesis by single bead IR and fluorescence
spectroscopy. Tetrahedron Lett 38, 6485-6488, 1997.
Marti R, Yan B,
Jarosinski M. Solid phase synthesis via 5-oxazolidinones. Ring opening reactions with amines and reaction
monitoring by single bead FTIR microspectroscopy. J Org Chem 62, 5615-5618, 1997.
Lin SL, Yan B. Three
dimentional model of sensory rhodopsin I reveals important restraints between the protein and the chromophore.
Protein Engineering 10, 197-206, 1997.
Yan B, Spudich EN,
Sheves M, Spudich JL. Complexation of the signal transducing protein HtrI to sensory rhodopsin I and its effect on
thermodynamics of signaling state deactivation. J Phys Chem B 101, 109-113, 1997.
1996
Yan B, Gstach H.
Monitoring of solid-phase heterocyclic chemistry by Single bead IR. Tetrahedron Lett 37, 8325-8328, 1996.
Yan B, Sun Q,
Wareing JR, Jewell CF. Real-time Monitoring of the Catalytic Oxidation of Alcohols on Resin Supports by Single
Bead FTIR Microspectroscopy. J Org Chem 61, 8765-8770, 1996.
Yan B, Kumaravel G.
Probing solid-phase reactions by monitoring the IR bands of compounds on a single "flattened" resin
bead. Tetrahedron 52, 843-848, 1996.
Yan B, Fell JB,
Kumaravel G. Progression of organic reactions on resin supports monitored by single bead FTIR microspectroscopy. J
Org Chem 61, 7467-7472, 1996.
Highlighted
by CHEMTRACTS-ORGANIC CHEMISTRY 10:822-827, 1997.
1995
Yan B, Spudich JL,
Mazur P, Vunnam S, Derguini F, Nakanishi K. Spectral tuning in bacteriorhodopsin in the absence of counterion and
coplanarization effects. J Biol Chem 270, 29668-29670, 1995.
Yan B, Kumaravel G,
Anjaria H, Wu A, Petter RC, Jewell CF, Wareing J. Infrared spectrum of a single resin bead for real-time
monitoring of solid-phase reactions. J Org Chem 60, 5736-5738, 1995.
Selected as
Bio-Rad Application Note in 1996.
Mann, W. R., Yan,
B., Dragland, C. J. and Bell, P. A. ¡°Kinetics, circular dichroism, and fluorescence studies on heterologously
expressed carnitine palmitoyltransferase II,¡± J. Enzyme Inhibition. 1995, 9, 303-308.
Yan B, Mann WR, Bell
P. Substrate-induced conformational changes in carnitine acetyltransferase. Biochim Biophys Acta 1253, 175-180,
1995.
Before
1995
Yan B, Xie A,
Nienhaus GU, Katsuta Y, Spudich JL. Steric constraints in the retinal binding pocket of sensory rhodopsin I.
Biochemistry 32, 10224-10232, 1993.
Yan B, Cline S,
Doolittle WF, Spudich JL. Transformation of a BOP-HOP-SOP-I-SOP-II- Halobacterium halobium mutant to BOP+: effects
of bacteriorhodopsin photoactivation on cellular proton fluxes and swimming behavior. Photochem Photobiol 56,
553-561, 1992.
Yan, B., Cline, S.,
Doolittle, W. F. & Spudich, J. L. ¡°Transformation of a bop-hop-sop-i-sop-ii- h-halobium mutant to bop+ -
effects of bacteriorhodopsin photoactivation on cellular proton fluxes and swimming behavior,¡± FASEB J. 6, A531.
1992.
Takahashi, T; Yan,
B; Spudich, JL, Sensitivity increase in the photophobic response of halobacterium-halobium reconstituted with
retinal analogs - a novel interpretation for the fluence-response relationship and a kinetic modeling, Joint Us /
Japan Seminar On The Biophysical Chemistry Of Retinal Proteins, 56, 1119-1128, 1992.
Takahashi T, Yan B,
Spudich JL. Sensitivity increase in the photophobic response of Halobacterium halobium reconstituted with retinal
analogs: a novel interpretation for the fluence-response relationship and a kinetic modeling. Photochem Photobiol
56, 1119-1128, 1992.
Ratto GM, Robinson
DW, B Yan, McNaughton PA. Development of the light response in neonatal mammalian rods. Nature 351, 654-657, 1991.
Yan, B., R. Johnson,
E.N. Spudich, K. Nakanishi & J.L. Spudich, Photoactivation of sensory rhodopsin I (SR-I): Some differences
from bacteriorhodopsin and similarities to rhodopsin. Biophys. J. 59, 555A, 1991.
Yan B, Nakanishi K,
Spudich JL. Mechanism of activation of sensory rhodopsin I: evidence for a steric trigger. Proc Natl Acad Sci USA
88, 9412-9416, 1991.
Ratto, G.M., D.W.
Robinson, B. Yan & P.A. McNaughton. ¡°In vitro studies on the mechanism underlying the low sensitivity of
neonatal rat rods,¡± J. Physiol. 1991, 438, 205p.
Yan B, Spudich JL.
Evidence that the repellent receptor form of sensory rhodopsin I is an attractant signaling state. Photochem
Photobiol 54, 1023-1026, 1991.
Yan B, Takahashi T,
Johnson R, Spudich JL. Identification of signaling states of a sensory receptor by modulation of lifetimes of
stimulus-induced conformations: the case of sensory rhodopsin II. Biochemistry 30, 10686-10692, 1991.
Yan B, Takahashi T,
McCain DA, Rao VJ, Nakanishi K, Spudich JL. Effects of modifications of the retinal b-ionone ring on
archaebacterial sensory rhodopsin I. Biophys J 57, 477-483, 1990.
Yan B, Takahashi T,
Johnson R, Derguini F, Nakanishi K, Spudich JL. All-trans/13-cis isomerization of retinal is required for
phototaxis signaling by sensory rhodopsins in halobacterium halobium. Biophys J 57, 807-814, 1990.
Takahashi T, Yan B,
Mazur P, Derguini F, Nakanishi K, Spudich JL. Color regulation in the archaebacterial phototaxis receptor
phoborhodopsin (sensory rhodopsin II). Biochemistry 29, 8467-8474, 1990.
Takahashi T, Yan B,
Rao B, Nakanishi K, Spudich JL. Retinal analogs reconstitutions of bacterial sensory rhodopsin I. Biophys J 55,
383, 1989.
